Please use this identifier to cite or link to this item: http://hdl.handle.net/10267/33435
Title: Diels-Alder Reaction to Synthesize Biologically Active Molecules
Authors: Wittwer, Emmaline A.
Advisors: Horgen, Dana
Keywords: URCAS;Student research;2018 Spring;Class of 2020;Chemistry, Department of;Cancer
Issue Date: 27-Apr-2018
Abstract: An ethanol extract from the roots of Boesenbergia pandurate shows bioactivity which is harmful to the cells of PANC-1 human pancreatic cancer. Additionally, fifteen other molecules have been identified via purification of the extract. Dr. Horgen's lab is working to synthesize these compounds. All of the target compounds have a similar core structure. We will work to make this core structure using a Diels-Alder reaction. This reaction will use a catalyst, aluminum hexagonal silica (Al-HMS), which will be synthesized from tetraethyl orthosilicate, aluminum isopropoxide and hexadecylamine. The use of this catalyst has been shown to lead to high yields in the Diels-Alder reactions between similar diene and chalcone dieneophiles. Finding a reliable way to make this core structure will provide the first step in a route to make the identified biologically active compounds that could be used to create an anticancer drug.
Description: Presentation by Emmaline Wittwer ('20) delivered at the Rhodes College Undergraduate Research and Creative Activity Symposium (URCAS).
URI: http://hdl.handle.net/10267/33435
Appears in Collections:Undergraduate Research and Creative Activity Symposium

Files in This Item:
File Description SizeFormat 
201804_Wittwer_Emmaline_DielsAlderReaction_Poster.pdf5.14 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.